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Statistics in toxicology WS201920


Link to moodle of this course: [Statistics in Toxicology, LSF, 050903]


General information



Lecture dates:

Monday, 10:15 - 11:45 in M/E 21

Tuesday, 08:30 - 10:00 in M/E 25

First lecture: October 7, 10:15 in M/E 21


Tutorial dates: TBA


Written exams: TBA



For admission to the written exam, 50% of the exercises points must be achieved.

The exercises will consist of theoretical and software exercises.

For the software exercises, you need to use R with R Markdown (


Slides of the course as well as all materials for the exercises can be found on the Moodle page of the course.


Content of the course

    The main topic of the lecture is the analysis of data from toxicology, especially dose-response measurements. Speci fic topics are:

    • Proof of hazard using simultaneous comparisons with a negative control

      • Multiple testing
      • Tests for normally distributed endpoints and tests for proportions
      • Trend tests

    • Analysis of long-term e ffects in cancer studies

      • Survival analysis, tests for survival endpoint

    • Analysis of eff ects in mutagenicity assays

      • Mixture distributions
      • EM algorithm

    • Grouping of profi les from multiple dose-response experiments

      • Cluster analysis

    • Statistical modelling of relationships between dose and response

      • Parametric models
      • Model selection, model averaging