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Dipl.-Stat. Birte Hellwig geb. Weibert

Statistische Methoden in der Genetik und Chemometrie

Kontakt

Birte Hellwig geb. Weibert
Mathematikgeb.,
Raum 728
0231 755 - 3118
0231 755 - 5303
Fakultät Statistik
Technische Universität Dortmund
44221 Dortmund


 

Sprechzeiten

nach Vereinbarung

 

Studium

  • Diplom (Statistik), Technische Universität Dortmund, 2009
    Thema: Genexpressionsdaten als Kovariablen in Überlebenszeitmodellen für Brustkrebspatientinnen

Wissenschaftliche Tätigkeiten

  • April 2009 - April 2011: wissenschaftliche Mitarbeiterin am Leibniz-Institut für Arbeitsforschung an der TU Dortmund (IfADo)
  • Seit Mai 2011: wissenschaftliche Mitarbeiterin an der TU Dortmund

Projektmitarbeit

DFG-Projekt RA 870/5-1: Verbesserte prognostische Signaturen aus Microarray-Studien durch Auswahl von Genen mit charakteristischen Verteilungen

 

Arbeitsgebiete

  • Statistische Analyse von Genexpressionsdaten
  • Überlebenszeitanalyse

 

Publikationen

2016

  • Mikheil Gogiashvili, Karolina Edlund, Kathrin Gianmoena, Rosemarie Marchan, Alexander Brik, Jan T. Andersson, Jörg Lambert, Katrin Madjar, Birte Hellwig, Jörg Rahnenführer, Jan G. Hengstler, Roland Hergenröder and Cristina Cadenas. Metabolic profiling of ob/ob mouse fatty liver using HR-MAS 1H-NMR combined with gene expression analysis reveals alterations in betaine metabolism and the transsulfuration pathway. Analytical and Bioanalytical Chemistry, pages 1-16, 2016. [DOI]
  • Birte Hellwig, Katrin Madjar, Karolina Edlund, Rosemarie Marchan, Cristina Cadenas, Anne-Sophie Heimes, Katrin Almstedt, Antje Lebrecht, Isabel Sicking, Marco J. Battista, Patrick Micke, Marcus Schmidt, Jan G. Hengstler and Jörg Rahnenführer. Epsin Family Member 3 and Ribosome-Related Genes Are Associated with Late Metastasis in Estrogen Receptor-Positive Breast Cancer and Long-Term Survival in Non-Small Cell Lung Cancer Using a Genome-Wide Identification and Validation Strategy. PLOS ONE, vol. 11 no. 12, page e0167585, December 2016. [DOI]

2015

  • Miriam Lohr, Birte Hellwig, Karolina Edlund, Johanna S.M. Mattsson, Johan Botling, Marcus Schmidt, Jan G. Hengstler, Patrick Micke and Jörg Rahnenführer. Identification of sample annotation errors in gene expression datasets. Archives of Toxicology, vol. 89 no. 12, pages 2265-2272, Dec 2015.

2014

  • Cristina Cadenas, Leonie van de Sandt, Karolina Edlund, Miriam Lohr, Birte Hellwig, Rosemarie Marchan, Marcus Schmidt, Jörg Rahnenführer, Henrik Oster and Jan G. Hengstler. Loss of circadian clock gene expression is associated with tumor progression in breast cancer. Cell Cycle, vol. 13 no. 20, pages 3282-3291, 2014.
  • Patricio Godoy, Cristina Cadenas, Birte Hellwig, Rosemarie Marchan, Joanna Stewart, Raymond Reif, Miriam Lohr, Matthias Gehrmann, Jörg Rahnenführer, Markus Schmidt and Jan G. Hengstler. Interferon-inducible guanylate binding protein (GBP2) is associated with better prognosis in breast cancer and indicates an efficient T cell response. Breast Cancer, vol. 21 no. 4, pages 491-499, July 2014. [DOI]
  • Cecilia Lindskog, Linn Fagerberg, Björn Hallström, Karolina Edlund, Birte Hellwig, Jörg Rahnenführer, Caroline Kampf, Mathias Uhlén, Fredrik Pontén and Patrick Micke. The lung-specific proteome defined by integration of transcriptomics and antibody-based profiling. The FASEB Journal, pages fj.14-254862, August 2014. [DOI]

2013

  • Johan Botling, Karolina Edlund, Miriam Lohr, Birte Hellwig, Lars Holmberg, Mats Lambe, Anders Berglund, Simon Ekman, Michael Bergqvist, Fredrik Pontén, André König, Oswaldo Fernandes, Mats Karlsson, Gisela Helenius, Christina Karlsson, Jörg Rahnenführer, Jan G. Hengstler and Patrick Micke. Biomarker Discovery in NonCell Lung Cancer: Integrating Gene Expression Profiling, Meta-analysis, and Tissue Microarray Validation. Clinical Cancer Research, vol. 19 no. 1, pages 194-204, January 2013. [DOI]
  • Miriam Lohr, Karolina Edlund, Johan Botling, Seddik Hammad, Birte Hellwig, Amnah Othman, Anders Berglund, Mats Lambe, Lars Holmberg, Simon Ekman, Michael Bergqvist, Fredrik Pontén, Cristina Cadenas, Rosemarie Marchan, Jan G. Hengstler, Jörg Rahnenführer and Patrick Micke. The prognostic relevance of tumour-infiltrating plasma cells and immunoglobulin kappa C indicates an important role of the humoral immune response in non-small cell lung cancer. Cancer Letters, vol. 333 no. 2, pages 222-228, June 2013. [DOI]

2012

  • Cristina Cadenas, Sonja Vosbeck, Eva-Maria Hein, Birte Hellwig, Alice Langer, Heiko Hayen, Dennis Franckenstein, Bettina Büttner, Seddik Hammad, Rosemarie Marchan, Matthias Hermes, Silvia Selinski, Jörg Rahnenführer, Begüm Peksel, Zsolt Török, László Vıgh and Jan G. Hengstler. Glycerophospholipid profile in oncogene-induced senescence.. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1821 no. 9, pages 1256-68, September 2012. [DOI]
  • Tanja Heise, Markus Schug, Dorothe Storm, Heidrun Ellinger Ziegelbauer, Hans-Jürgen Ahr, Birte Hellwig, Jörg Rahnenführer, Ahmed Ghallab, Georgia Guenther, Julia Sisnaiske, Raymond Reif, Patricio Godoy, Hans Mielke, Ursula Gundert Remy, Alfonso Lampen, Axel Oberemm and Jan G. Hengstler. In Vitro - In Vivo Correlation of Gene Expression Alterations Induced by Liver Carcinogens. Current Medicinal Chemistry, vol. 19 no. 11, pages 1721-1730, April 2012.
  • Miriam Lohr, Claudia Köllmann, Evgenia Freis, Birte Hellwig, Jan G. Hengstler, Katja Ickstadt and Jörg Rahnenführer. Optimal strategies for sequential validation of significant features from high-dimensional genomic data.. Journal of Toxicology and Environmental Health-Part A-Current Issues, vol. 75 no. 8-10, pages 447-60, January 2012. [DOI]
  • Marcus Schmidt, Birte Hellwig, Seddik Hammad, Amnah Othman, Miriam Lohr, Zonglin Chen, Daniel Boehm, Susanne Gebhard, Ilka Petry, Antje Lebrecht, Cristina Cadenas, Rosemarie Marchan, Joanna D. Stewart, Christine Solbach, Lars Holmberg, Karolina Edlund, Hanna Göransson Kultima, Achim Rody, Anders Berglund, Mats Lambe, Anders Isaksson, Johan Botling, Thomas Karn, Volkmar Müller, Aslihan Gerhold Ay, Christina Cotarelo, Martin Sebastian, Ralf Kronenwett, Hans Bojar, Hans-Anton Lehr, Ugur Sahin, Heinz Koelbl, Mathias Gehrmann, Patrick Micke, Jörg Rahnenführer and Jan G. Hengstler. A comprehensive analysis of human gene expression profiles identifies stromal immunoglobulin $C as a compatible prognostic marker in human solid tumors.. Clinical Cancer Research, vol. 18 no. 9, pages 2695-703, May 2012. [DOI]
  • Wulf Siggelkow, Daniel Boehm, Susanne Gebhard, Marco Battista, Isabel Sicking, Antje Lebrecht, Christine Solbach, Birte Hellwig, Jörg Rahnenführer, Heinz Koelbl, Mathias Gehrmann, Rosemarie Marchan, Cristina Cadenas, Jan G. Hengstler and Marcus Schmidt. Expression of aurora kinase A is associated with metastasis-free survival in node-negative breast cancer patients. BMC Cancer, vol. 12 no. 1, page 562, November 2012. [DOI]

2010

  • Jan C. Brase, Marcus Schmidt, Thomas Fischbach, Holger Sültmann, Hans Bojar, Heinz Kölbl, Birte Hellwig, Jörg Rahnenführer, Jan G. Hengstler and Mathias C. Gehrmann. ERBB2 and TOP2A in Breast Cancer: A Comprehensive Analysis of Gene Amplification, RNA Levels, and Protein Expression and Their Influence on Prognosis and Prediction. Clinical Cancer Research, vol. 16 no. 8, pages 2391-2401, April 2010. [DOI]
  • Birte Hellwig, Jan G Hengstler, Marcus Schmidt, Mathias C. Gehrmann, Wiebke Schormann and Jörg Rahnenführer. Comparison of scores for bimodality of gene expression distributions and genome-wide evaluation of the prognostic relevance of high-scoring genes. BMC Bioinformatics, vol. 11, 2010. [DOI]

2009

  • Evgenia Freis, Silvia Selinski, Birte Weibert, Ulrike Krahn, Marcus Schmidt, Mathias Gehrmann, Matthias Hermes, Lindsey Maccoux, Jonathan West, Holger Schwender, Jörg Rahnenführer, Jan G. Hengstler and Katja Ickstadt. Effects of metagene calculation on survival: An integrative approach using cluster and promoter analysis. In Proceedings of the Sixth International Workshop on Computational Systems Biology (WCSB 2009), pages 47-50, Aarhus, 2009.