Extraktion von genregulatorischen Netzwerken und Protein Aktivierungskaskaden mit Hilfe von Bayesschen Netzwerken
Grzegorczyk, M. (2010): An Introduction to Gaussian Bayesian Networks. In Yan Qing (Ed.): Systems Biology in Drug Discovery and Development (Springer Series: Methods in Molecular Biology, Vol. 662). Humana Press. ISBN 978-1-60761-799-0 [Due: August 29, 2010]
Grzegorczyk M.; Husmeier, D.; and Rahnenführer, J. (2010): Modelling non-stationary dynamic gene regulatory processes with the BGM model, Computational Statistics, In Press. [online version]
Lohr M.; Godoy P.; Hengstler J.G.; Rahnenführer J.; and Grzegorczyk M. (2010): In: T. Manninen et al. (eds.): Extracting differential regulatory sub-networks from genome-wide microarray expression data. Proceedings of the Seventh International Workshop on Computational Systems Biology, WCSB 2010, Luxembourg, 63-66. [no online link yet]
Grzegorczyk M.; Husmeier, D.; and Rahnenführer, J. (2010): Modelling Non-Stationary Gene Regulatory Processes, Advances in Bioinformatics, Volume 2010, Article ID 749848 [available here]
Grzegorczyk M.; and Husmeier, D. (2009): Non-stationary continuous dynamic Bayesian networks. In Bengio, Schuurmans, Lafferty, Williams and Culotta (editors) Proceedings of the Twenty-Third Annual Conference on Neural Information Processing Systems (NIPS 2009), Curran Associates, ISBN 9781605603520, 682-690. [available here]
Grzegorczyk M.; and Husmeier, D. (2009): Avoiding Spurious Feedback Loops in the Reconstruction of Gene Regulatory Networks with Dynamic Bayesian Networks. In: V. Kadirkamanathan et al. (eds.): Pattern Recognition in Bioinformatics, Lecture Notes in Bioinformatics, Springer-Verlag Berlin Heidelberg, 113-124. [abstract]
Grzegorczyk M.; and Husmeier, D. (2009): Modelling non-stationary gene regulatory processes with a non-homogeneous dynamic Bayesian network and the change point process. In: T. Manninen et al. (eds.): Proceedings of the Sixth International Workshop on Computational Systems Biology, WCSB 2009, Aarhus, Denmark, ISBN 978-952-15-2160-7, 51-54. [proceedings available here]
Grzegorczyk, M.; Husmeier, D.; Edwards, D.E.; Ghazal, P.;and Millar, A.J. (2008): Modelling non-stationary gene regulatory processes with a non-homogeneous Bayesian network and the allocation sampler. Bioinformatics, 24, 2071-2078. [available here]
Grzegorczyk, M.; and Husmeier, D. (2008): Improving the structure MCMC sampler for Bayesian networks by introducing a new edge reversal move. Machine Learning, 71, 265-305. [abstract]
Grzegorczyk, M. (2008): Comparison of two different stochastic models for extracting protein regulatory pathways with Bayesian networks. Journal of Toxicology and Environmental Health, Part A, 71, 780–787. [abstract]
Grzegorczyk, M.; Husmeier, D.; and Werhli, A.V. (2008) Reverse Engineering Gene Regulatory Networks with various Machine Learning Methods. In Emmert-Streib, F. / Dehmer, M. (editors) Analysis of Microarray Data. A Network-Based Approach, Wiley-WCH. [book contents]
Grzegorczyk, M. (2007): Extracting protein regulatory networks with graphical models. Proteomics, 7 (S1), 51-59. [abstract]
Grzegorczyk, M. (2006): Comparative evaluation of different Graphical Models for the Analysis of Gene Expression Data. Doctoral Thesis, Department of Statistics, University of Dortmund [thesis available here]
Urfer, W.; Grzegorczyk, M.; and Jung, K. (2006): Statistics for Proteomics: A review of tools for analyzing experimental data. Proteomics, 6 (S2), 48-55. [abstract]
Werhli, A.V.; Grzegorczyk, M.; and Husmeier, D. (2006): Comparative evaluation of reverse engineering gene regulatory networks with relevance networks, graphical Gaussian models and Bayesian networks. Bioinformatics, 22, 2523-2531. [available here]
Sievers, S.; Fritsch, C.; Grzegorczyk, M.; Kuhnen, C.; and Müller, O. (2006): Absolute ß-catenin concentrations in Wnt pathway stimulated and non-stimulated cells. Biomarkers, 11 (3), 270-278. [abstract]
Werhli, A.V.; Grzegorczyk, M.; Chiang, M.T; and Husmeier, D. (2006): Improved Gibbs sampling for detecting mosaic structures in DNA sequence alignments In: Urfer W. and Turkman M. A. (editors) Statistics in Genomics and Proteomics, Centro Internacional de Matematica, Coimbra. [proceedings]
Kutzner, N.; Hoffmann, I.; Linke, C.; Thienel, T.; Grzegorczyk, M.; Urfer, W.; Martin, D.; Winde, G.; Traska, T.; Hohlbach, G.; Müller, K.-M.; Kuhnen, C. and Müller, O. (2005): Non-invasive detection of colorectal tumours by the combined application of molecular diagnosis and the faecal occult blood test. Cancer Letters, 1, 33-41. [abstract]
Grzegorczyk, M. (2007) Reverse engineering gene and protein regulatory networks using graphical models: A comparative evaluation study. Talk at PASCAL workshop on Probabilistic Modelling of Biological Networks and Pathways. 04-05 September 2007, Sheffield, Videolecture and slides available from [Videolectures.net]
Genetische Netzwerke SS2009 (2V+1Ü) [Vorlesungsfolien]
Genetische Netzwerke SS2010 (2V+1Ü) [Vorlesungsfolien]
[V] Complex Stochastic Systems in Biology and Medicine (Munich, Germany, 7-8 october,2004) [webpage]
[P] Workshop on Statistics in Genomics and Proteomics (Monte Estoril, Portugal, 5-8 October, 2005) [webpage]
[V] Mathematical and Statistical Aspects of Molecular Biology (Dublin, Ireland, 10-11 April, 2006) [webpage]
[P] German Conference on Bioinformatics (Tübingen, Germany, 20-22 September, 2006) [webpage]
[V] Environmental Toxicology in North Rhine-Westphalia (Dortmund, Germany, 10-11 May, 2007) [webpage]
[V] Probabilistic Modelling of Networks and Pathways (Sheffield, England, 4-5 September, 2007) [webpage]
[V] 55. Biometrisches Kolloquium (Hannover, Germany, 17-19 March, 2009)[webpage]
[v] 6th Workshop on Computational Systems Biology (Aarhus, Denmark, 10-12 June, 2009) [webpage]
[v] Statistical Computing (Schloss Reisensburg, Germany, 28 June - 1 Juli, 2009) [webpage]
[v] Pattern Recognition in Bioinformatics (Sheffield, England, 7-9 September, 2009) [webpage]
[v] Kolloquium der Deutschen Arbeitsgemeinschaft Statistik (Dortmund, Germany, 23-26 March, 2010) [webpage]
[V] Statistical Computing (Schloss Reisensburg, Germany, 20-23 June, 2010) [webpage] [Tutorial zipped download]
[P] Annual International Conference on Intelligent Systems for Molecular Biology (Fortaleza, Brazil, 6-10 August, 2006) [webpage]
[V] Mathematical and Statistical Aspects of Molecular Biology (London, England, 2-3 April, 2009) [webpage]
[P] 23rd Annual Conference on Neural Information Processing Systems (Vancouver, B.C., Canada, 7-10 December, 2009) [webpage]
[V] 7th Workshop on Computational Systems Biology (Luxembourg, 16-18 June, 2010) [webpage]